Endoscopic molecular imaging of human bladder cancer using a CD47 antibody

, 260ra148 (2014); 6 Sci Transl Med et al. Ying Pan antibody Endoscopic molecular imaging of human bladder cancer using a CD47 Editor's Summary imaging approach to diagnosing various bladder cancers will translate after further optimization. administration of a fluorescent antibody and the use of already available clinical tools, it is hoped that this molecular a diagnostic challenge for white light imaging. Because this approach only requires topical −− carcinoma in situ lesions authors reported a sensitivity of 82.9% and a specificity of 90.5%. They further correctly identified five of six patients. Overall, 119 bladder regions were analyzed using the fluorescent antibody and blue light cystoscopy. The instilled into human bladders with muscle and nonmuscle invasive cancer that had been recently removed from authors attached a brightly fluorescent tag, called a quantum dot, to a CD47 antibody. The fluorescent antibody was targeted the cancer-specific marker CD47 that is present on the surface of solid tumors, including in the bladder. The et al. based imaging that looks for superficial tissue changes, such as color and texture. To this end, Pan − light Molecular imaging of bladder cancer could greatly improve on current methods of diagnosis, which rely on white Lighting Up Bladder Cancer Lesions